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- Esta colección contiene documentos patrimoniales que ha producido y resguarda la Universidad Católica Boliviana "San Pablo"
- CReA VLIR-UOS es un programa de Cooperación Interuniversitaria que busca fortalecer las capacidades académicas y administrativas para mejorar la investigación y formación en la Universidad Católica Boliviana (UCB) en todas sus regionales. Además de fortalecer los centros e institutos de investigación por igual, al tiempo que mejora el trabajo transdisciplinario de los investigadores en cada regional
- Sobre FuGAR Chiquitania de la UCB: FuGAR Chiquitania es una iniciativa de investigación que surge del equipo de investigadores del Centro de Investigación en Ciencias Exactas e Ingenierías (CICEI) de la Universidad Católica Boliviana “San Pablo”, regional Cochabamba, apoyado por fondos PISCCA 2020 de la Embajada de Francia en Bolivia.
Recent Submissions
Navigating ambiguous waters: a relational approach to nested conflicts in the Katari River Basin, Bolivia
(2025-05) Agramont, Afnan; Villlafuerte Philippsborn, Leonardo D.; Peres-Cajias, Guadalupe; Baltodano Martinez, Analy; Van Griensven, Ann; Craps, Marc; Brugnach, Marcela F.
The Katari River Basin, the most densely populated basin in Bolivia, discharges into Lake Titicaca, the world’s highest
navigable lake and a crucial water resource in the Andes. Despite its significance, the basin suffers from severe water contamination
because of anthropogenic activities. This pollution adversely affects water quality, distribution, and availability, exacerbating the region’s
vulnerability to the impacts of climate change at high elevations. In response to these challenges, the Bolivian government established
a multi-stakeholder platform. However, this platform reveals complex water conflict dynamics linked to ambiguity associated with
different ways of knowing, framing, and coping with water pollution issues. This study examines how relational practices are linked to
managing ambiguity and addressing nested water conflicts. Relational practices are communication-based practices by which the
involved actors shape and develop mutual and shared sense-making relationships. Our findings reveal that current relational practices
hinder their ability to collaboratively address ambiguities, leaving underlying water conflicts unresolved. Moreover, they indicate that
ambiguity is managed by imposing a singular frame, reinforced by the significant power asymmetries within the multi-stakeholder
platform, strengthening the dynamics of water conflicts. We conclude that dealing with ambiguity through high-quality relational
practices could facilitate the recognition and resolution of water conflicts, potentially improving clarity, communication, and advancing
collaborative problem-solving among stakeholders
Efficacy of Protein-Based Therapies in Modulating Pathology and Symptoms of Alzheimer’s Disease: A Systematic Review
(2024) Rivero Paniagua, Yhazmin; Feeney Camacho, Nicole; Urioste Daza, Jhuliana; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Introduction:
Beta-amyloid plaques and tau neurofibrillary tangles disrupt brain function, leading to the progressive cognitive and functional decline characteristic of Alzheimer’s Disease (AD). Current treatments provide only symptomatic relief, failing to address the underlying pathology. Protein-based therapies, including monoclonal antibodies and recombinant protein vaccines, aim to target these pathological mechanisms by clearing beta-amyloid deposits and modulating tau activity. This review evaluates the efficacy of these therapies in improving cognitive and functional outcomes while exploring their limitations and potential.
Methods:
This systematic review was conducted following PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions (version 6.3). A comprehensive search of PubMed, Scopus, and Web of Science was performed. Inclusion criteria focused on studies evaluating protein-based therapies targeting amyloid-beta or tau in Alzheimer’s Disease. Data on cognitive and functional outcomes, safety, and biomarkers were extracted and synthesized to identify trends and gaps in the evidence.
Results:
Eight studies involving 724 participants met the inclusion criteria. Monoclonal antibodies, such as aducanumab, reduced amyloid-beta plaques within 24–48 weeks, but cognitive improvements were inconsistent. Recombinant vaccines, like Lu AF20513, induced strong immune responses in 65–80% of patients, especially with immunostimulant patches. Biomarkers such as alpha-2-macroglobulin showed promise in monitoring treatment efficacy. Adverse events, including mild infusion reactions, were more frequent with antibody therapies, highlighting the need for further optimization.
Conclusion:
Protein-based therapies show potential in Alzheimer’s Disease treatment by targeting amyloid-beta plaques and tau pathology. Monoclonal antibodies and recombinant vaccines offer promising results in reducing pathological hallmarks and improving immune responses. However, cognitive and functional benefits remain inconsistent, and adverse events are common. Further research is necessary to optimize these therapies, validate biomarkers, and ensure broader clinical applicability.
Efficacy and safety of trofinetide in patients with Rett syndrome: a systematic literature review
(2024) Menacho Meroly, Saucedo Camila
Introduction
Rett syndrome (RTT) is a rare neurodevelopmental disorder with limited treatment
options. Trofinetide has emerged as a potential therapeutic agent due to its
neuroprotective and anti-inflammatory properties. This systematic review evaluates
the efficacy and safety of trofinetide in patients with Rett syndrome.
Methods
We identified 44 articles from two databases (PubMed and Scopus). After removing
duplicates, we applied the inclusion criteria, which were restricted to systematic
reviews and meta-analyses of randomized controlled trials (RCTs) published within
the last 5 years, available in English, and reporting efficacy outcomes measured with
validated tools such as the Rett Syndrome Behavior Questionnaire (RSBQ) and the
Clinical Global Impression-Improvement (CGI-I). Non-randomized trials and studies
with insufficient data were excluded.
Results
This review included three studies with 916 patients on trofinetide for Rett syndrome.
Trofinetide showed significant improvements in RSBQ (MD: -3.40 to -3.53) and CGI-I
scores (MD: -0.34 to -0.35). Common side effects were diarrhea and vomiting, but no
severe adverse events were reported.
Conclusions
This systematic review supports the efficacy of trofinetide in improving behavioral
and functional outcomes in Rett syndrome. The treatment demonstrated significant
reductions in symptom severity, particularly in communication and motor skills, as
measured by the Rett Syndrome Behavior Questionnaire (RSBQ) and Clinical Global
Impression-Improvement (CGI-I). While trofinetide was generally well-tolerated,
common side effects like diarrhea and vomiting were reported. Further research with
longer follow-up periods is needed to confirm the long-term efficacy and safety of
trofinetide in RTT patients.
Botulinum Toxin as an Adjunct Treatment for Borderline Personality Disorder: A systematic Review of 144 Patients
(2024) Cespedes Canavire, Sedrich; Osorio Ortega, Valentina; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)