Browsing by Author "Hjeala-Varas, Amir"

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    Intraoperative ultrasound for surgical resection of high-grade glioma and glioblastoma: a meta-analysis of 732 patients
    (Neurosurgical Review, 2024) Pichardo-Rojas, Pavel S.; Zarate, Carlos; Arguelles-Hernández, Julieta; Barrón-Lomelí, Aldo; Sanchez-Velez, Roberto; Hjeala-Varas, Amir; Gutierrez-Herrera, Ernesto; Tandon, Nitin; Esquenazi, Yoshua
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    Surgical Management of Acute Subdural Hematoma: A Meta-Analysis
    (Neurosurgery, 2024) Pichardo-Rojas, Pavel S.; Rodriguez-Elvir, Francisco A.; Hjeala-Varas, Amir; Sanchez-Velez, Roberto; Portugal-Beltrán, Emma; Barrón-Lomelí, Aldo; Freeman, Priscilla I.; Dono, Antonio; Kitagawa, Ryan; Esquenazi, Yoshua
    Abstract Background and objective: Traumatic acute subdural hematoma (ASDH) is a medical emergency that requires prompt neurosurgical intervention. Urgent surgical evacuation may be performed with craniotomy (CO) and decompressive craniectomy (DC). However, a meta-analysis evaluating confounders, pooled functional outcomes, and mortality analyses at different time points has not been performed. Methods: A systematic search was conducted until August 28, 2023. We identified studies performing ASDH evacuation with CO or DC. Outcomes included Glasgow Coma Scale (GCS), Glasgow Outcome Scale (GOS), GOS-Extended, mortality, procedure-related complications, and reoperation. Variables were assessed using risk ratio (RR) and mean difference. Results: Among 684 published articles, we included the Randomized Evaluation of Surgery with Craniectomy for Patients Undergoing Evacuation of ASDH (RESCUE-ASDH) trial, 4 propensity score-matched (PSM) cohorts, and 13 observational cohort studies. A total of 8886 patients underwent CO or DC. GCS at admission in unmatched cohorts was significantly worse in the DC group (mean difference = 2.20 [95% CI = 1.86-2.55], P < .00001). GOS-Extended scores were similar among CO and DC (RR = 1.10 [95% CI = 0.85-1.42], P = .49), including the RESCUE-ASDH trial. GOS at the last follow-up in unmatched cohorts significantly favored CO (RR = 1.66 [95% CI = 1.02-2.70], P = .04). Similarly, while short-term mortality favored CO over DC (RR = 0.69 [95% CI = 0.51-0.93], P = .02), both the RESCUE-ASDH trial and the PSM-cohorts yielded similar mortality rates among groups (P > .05). Mortality at the last follow-up in unmatched patients favored CO (RR = 0.60 [95% CI = 0.47-0.77], P < .0001). Procedure-related complications (RR = 0.74 [0.50-1.09], P = .12) and reoperation rates (RR = 0.74 [0.50-1.09], P = .12) were similar.