Sociedad Científica de Estudiantes de Medicina

Permanent URI for this collectionhttps://repositorio.ucb.edu.bo/handle/20.500.12771/153

MIEMBROS

  • Karina Mendez Frias
    		• Presidenta Kmf.lp.2095@gmail.com
  • Yrma Vanessa Ramirez Moreira
    		• Vicepresidenta Vanessara1@hotmail.com
  • Leonardo Dante Diaz Terrazas
    		• Secretario leodiazt@hotmail.com
  • Valery Stefany Hurtado Perez
    		• Tesorera stefanihp@hotmail.com

PROYECTOS EN EJECUCUCIÓN 2018

Proyectos Estudiantes involucrados
Estudio de prevalencia de demencia senil en pacientes mayores a 65 años en la sala de medicina interna del hospital San Juan de Dios en el período de agosto a noviembre del 2018. Ximena Tejerina, Harold Herbas, Dana Arano
Diagnóstico de la situación laboral del personal de salud, y su influencia sobre la calidad de los servicios de asistencia que brindan a la población de cobertura del “Centro de Salud San Carlos” durante el mes de agosto del año 2018 Karina Mendez Frias, Yasmina Mendoza, Dalia Puma

Browse

Filters

2021 - 202424

Settings

Search Results

Now showing 1 - 10 of 24
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
    Efficacy of Protein-Based Therapies in Modulating Pathology and Symptoms of Alzheimer’s Disease: A Systematic Review
    (2024) Rivero Paniagua, Yhazmin; Feeney Camacho, Nicole; Urioste Daza, Jhuliana; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
    Introduction: Beta-amyloid plaques and tau neurofibrillary tangles disrupt brain function, leading to the progressive cognitive and functional decline characteristic of Alzheimer’s Disease (AD). Current treatments provide only symptomatic relief, failing to address the underlying pathology. Protein-based therapies, including monoclonal antibodies and recombinant protein vaccines, aim to target these pathological mechanisms by clearing beta-amyloid deposits and modulating tau activity. This review evaluates the efficacy of these therapies in improving cognitive and functional outcomes while exploring their limitations and potential. Methods: This systematic review was conducted following PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions (version 6.3). A comprehensive search of PubMed, Scopus, and Web of Science was performed. Inclusion criteria focused on studies evaluating protein-based therapies targeting amyloid-beta or tau in Alzheimer’s Disease. Data on cognitive and functional outcomes, safety, and biomarkers were extracted and synthesized to identify trends and gaps in the evidence. Results: Eight studies involving 724 participants met the inclusion criteria. Monoclonal antibodies, such as aducanumab, reduced amyloid-beta plaques within 24–48 weeks, but cognitive improvements were inconsistent. Recombinant vaccines, like Lu AF20513, induced strong immune responses in 65–80% of patients, especially with immunostimulant patches. Biomarkers such as alpha-2-macroglobulin showed promise in monitoring treatment efficacy. Adverse events, including mild infusion reactions, were more frequent with antibody therapies, highlighting the need for further optimization. Conclusion: Protein-based therapies show potential in Alzheimer’s Disease treatment by targeting amyloid-beta plaques and tau pathology. Monoclonal antibodies and recombinant vaccines offer promising results in reducing pathological hallmarks and improving immune responses. However, cognitive and functional benefits remain inconsistent, and adverse events are common. Further research is necessary to optimize these therapies, validate biomarkers, and ensure broader clinical applicability.
  • No Thumbnail Available
    Item
    Efficacy and safety of trofinetide in patients with Rett syndrome: a systematic literature review
    (2024) Menacho Meroly, Saucedo Camila
    Introduction Rett syndrome (RTT) is a rare neurodevelopmental disorder with limited treatment options. Trofinetide has emerged as a potential therapeutic agent due to its neuroprotective and anti-inflammatory properties. This systematic review evaluates the efficacy and safety of trofinetide in patients with Rett syndrome. Methods We identified 44 articles from two databases (PubMed and Scopus). After removing duplicates, we applied the inclusion criteria, which were restricted to systematic reviews and meta-analyses of randomized controlled trials (RCTs) published within the last 5 years, available in English, and reporting efficacy outcomes measured with validated tools such as the Rett Syndrome Behavior Questionnaire (RSBQ) and the Clinical Global Impression-Improvement (CGI-I). Non-randomized trials and studies with insufficient data were excluded. Results This review included three studies with 916 patients on trofinetide for Rett syndrome. Trofinetide showed significant improvements in RSBQ (MD: -3.40 to -3.53) and CGI-I scores (MD: -0.34 to -0.35). Common side effects were diarrhea and vomiting, but no severe adverse events were reported. Conclusions This systematic review supports the efficacy of trofinetide in improving behavioral and functional outcomes in Rett syndrome. The treatment demonstrated significant reductions in symptom severity, particularly in communication and motor skills, as measured by the Rett Syndrome Behavior Questionnaire (RSBQ) and Clinical Global Impression-Improvement (CGI-I). While trofinetide was generally well-tolerated, common side effects like diarrhea and vomiting were reported. Further research with longer follow-up periods is needed to confirm the long-term efficacy and safety of trofinetide in RTT patients.
  • No Thumbnail Available
    Item
    Botulinum Toxin as an Adjunct Treatment for Borderline Personality Disorder: A systematic Review of 144 Patients
    (2024) Cespedes Canavire, Sedrich; Osorio Ortega, Valentina; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
  • No Thumbnail Available
    Item
    Consequences of inadequate exclusive breastfeeding in Children from latin america: a systematic review
    (2024) Franco, Sergio; Salazar, Mateo; Vilca, Najhavy; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
    Introduction: Exclusive breastfeeding is essential for the healthy growth and physical and mental development of your baby. Not breastfeeding or breastfeeding for less than six months increases the risk of the child developing various diseases. Objective: To gather and explain the consequences of not providing exclusive breastfeeding to children in Latin America. Methodology: Scientific articles were searched on the PubMed and Scielo platforms, following the PRISMA method. Specific criteria were used to decide which articles to include or exclude in this study. In total, 13 selected articles were analyzed. Results: The reviewed research shows that insufficient breastfeeding or breastfeeding for less than six months can lead to issues such as developmental and growth delays, overweight and obesity during adolescence, and underweight in childhood. It also indicates a high risk of respiratory diseases such as pneumonia and bronchiolitis, skin problems like allergic dermatitis and atopic dermatitis, iron deficiency anemia, vitamin A deficiency, and severe dehydration. Conclusion: It is important to have new information about the risks of breastfeeding in our society. This helps people understand its significance in preventing diseases and ensuring proper growth for babies.
  • No Thumbnail Available
    Item
    The Impact of Tranexamic Acid in Liver Resections: A Systematic Review
    (2024) Escalante Correa, Fabian; Aguirre Chavez, Ana Laura; Dencker Justiniano, Jorge; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
  • No Thumbnail Available
    Item
    Metabolic factors associated with kidney stone formation: a sistematic review
    (2024) Gutiérrez Montaño, Fernanda Ariana; Chavarría Cortez, Fiorella; Nina Masías, Rodrigo; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
    Kidney stones are a complex and multifactorial disease that affects a large proportion of the world's population. Metabolic factors, such as hypercalciuria, hypocitraturia, hyperoxaluria, and hyperuricosuria, play a crucial role in its development and recurrence. In this systematic review, these factors were analyzed to better understand their influence and contribute to clinical and preventive management. After an exhaustive search in electronic databases and a rigorous screening process, 12 relevant studies were included. The results showed that hypercalciuria affects 50-60% of patients with kidney stones, while hypocitraturia occurs in 60-80% of cases. Furthermore, systemic conditions such as metabolic syndrome and type 2 diabetes were associated with a significant increase in uric acid stone formation, underscoring the relationship between these diseases and lithogenesis. Preventive management based on dietary modifications, such as reducing sodium and animal protein consumption, combined with targeted pharmacological therapies, was shown to be effective in reducing stone recurrence. These findings highlight the importance of a preventive and personalized approach, although they also show the need for future research with more homogeneous methodologies. Identifying and addressing underlying metabolic factors is key to improving patients' quality of life.
  • No Thumbnail Available
    Item
    Depression, anxiety and stress in medical students during COVID-19 pandemic: A systematic review
    (2024) Cornejo Mollo, Shaaron Withney; Cruz Zambrana, Alejandra Janice; Encinas-Saucedo, Alejandra
  • No Thumbnail Available
    Item
    Prenatal and Postnatal Myelomeningocele repair A Systematic Review of Outcomes
    (2024) Pacheco, Camila; Vargas, Anhelle; Quiroga, Fernanda
  • No Thumbnail Available
    Item
    Effectiveness of psychological therapies versus antidepressants in adults with major depression: a systematic review
    (2024) Antelo Candia, Nohelia; Coronado Camacho, Génesis Jassid; Oshiro Nakagawa, Mie