Instituto de Investigación de Medicina

Permanent URI for this collectionhttps://repositorio.ucb.edu.bo/handle/20.500.12771/548

El Instituto de investigación de Medicina viene trabajando desde el año 2012 con el objetivo fundamental de mejorar la calidad de vida de los bolivianos mediante descubrimientos científicos en problemáticas como Chagas, tuberculosis y otras enfermedades infecciosas siendo esta una de sus líneas de investigación más robustecida, estos avances científicos se realizaron en colaboración con la Universidad John Hopkins y el SEDES.

Con investigaciones en las líneas de enfermedades infecciosas, salud mental y administración en salud el Instituto se encuentra formando una masa crítica de investigadores provenientes de la Sociedad Científica de Estudiantes, grupos de investigación y docentes investigadores de prestigio internacional.

Los resultados de las investigaciones en colaboración con la Universidad John Hopkins fueron publicados en revistas como Global Heart y Researchgate, y socializadas a la comunidad mediante SEMINARIOS INTERNACIONALES EN SALUD – ENFERMEDADES INFECCIONAS (Chagas, Tuberculosis y VIH), el año 2017 se realizó la segunda y tercera versión y contó con expositores de universidades de EEUU, Inglaterra y Perú.

LÍNEAS ESTRATÉGICAS DE INVESTIGACIÓN UCB “SAN PABLO” LÍNEAS ESPECÍFICAS DE INVESTIGACIÓN INSTITUTO DE INVESTIGACIÓN EN MEDICINA
1. Desarrollo humano integral: Derechos humanos, salud y educación L1: Investigación en enfermedades infecciosas, crónicas y no transmisibles.

L2: Estudios multidisciplinarios en salud mental.

L3: Calidad en la gestión de servicios de salud.

L4: Epidemiología medioambiental y laboral


PROYECTOS EN COLABORACIÓN

  • Valoración de la exposición a plaguicidas de trabajadores agrícolas del Departamento de Santa Cruz y evaluación del impacto en su salud LOGOS: INCADE, Ingeniería ambiental (UAGRM), Instituto de investigaciones de Humanidades (UAGRM), Universidad de Granada, España.
  • Validación del método MODS como cultivo para tuberculosis multidroga resistente (TB-MDR) en Santa Cruz de la Sierra, BOLIVIA. LOGOS: SEDES, Hospital San Juan de Dios
  • Obtención, caracterización y actividad bactericida de nanopartículas de plata soportadas en fibra de algodón LOGOS: Laboratorio Nacional de nanotecnologia del Brasil
  • Determinación de los factores asociados con la recuperación inmunológica y la carga viral en pacientes con VIH LOGOS CDVIR (Centro Departamental de Vigilancia y Referencia para el VIH)
  • Implementación de predictores de progresión de la cardiopatía en una cohorte con la enfermedad de chagas en Bolivia LOGO : Jhon Hopkins
  • Determinantes sociales de la salud en San José de Chiquitos LOGO San José de Chiquitos – U. libre de Bruselas

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Author: search.filters.author.Galdos-Cardenas, Gerson

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Now showing 1 - 5 of 5
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    Trypanosomacruzi-Infected Pregnant Women without Vector Exposure Have Higher Parasitemia Levels: Implications for Congenital Transmission Risk
    (2015-01-14) Rendell, Victoria R.; Gilman, Robert H.; Valencia, Edward; Galdos-Cardenas, Gerson; Verastegui, Manuela; Sanchez, Leny; Acosta, Janet; Sanchez, Gerardo; Ferrufino, Lisbeth; LaFuente, Carlos; Abastoflor, Maria del Carmen; Colanzi, Rony; Bern, Caryn
    Congenital transmission is a major source of new Trypanosoma cruzi infections, and as vector and blood bank control continue to improve, the proportion due to congenital infection will grow. A major unanswered question is why reported transmission rates from T.cruzi-infected mothers vary so widely among study populations. Women with high parasite loads during pregnancy are more likely to transmit to their infants, but the factors that govern maternal parasite load are largely unknown. Better understanding of these factors could enable prioritization of screening programs to target women most at risk of transmission to their infants.
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    Biomarkers in Trypanosomacruzi -Infected and Uninfected Individuals with Varying Severity of Cardiomyopathy in Santa Cruz, Bolivia
    (PLOS Neglected Tropical Diseases, 2014) Okamoto, Emi E.; Sherbuk, Jacqueline E.; Clark, Eva H.; Marks, Morgan A.; Gandarilla, Omar; Galdos-Cardenas, Gerson; Vasquez-Villar, Angel; Choi, Jeong
    Background: Twenty to thirty percent of persons with Trypanosoma cruzi infection eventually develop cardiomyopathy. If an early indicator were to be identified and validated in longitudinal studies, this could enable treatment to be prioritized for those at highest risk. We evaluated cardiac and extracellular matrix remodeling markers across cardiac stages in T. cruzi infected (Tc+) and uninfected (Tc2) individuals. Methods: Participants were recruited in a public hospital in Santa Cruz, Bolivia and assigned cardiac severity stages by electrocardiogram and echocardiogram. BNP, NTproBNP, CKMB, troponin I, MMP-2, MMP-9, TIMP-1, TIMP-2, TGFb1, and TGFb2 were measured in specimens from 265 individuals using multiplex bead systems. Biomarker levels were compared between Tc+ and Tc2 groups, and across cardiac stages. Receivers operating characteristic (ROC) curves were created; for markers with area under curve.0.60, logistic regression was performed. Results: Analyses stratified by cardiac stage showed no significant differences in biomarker levels by Tc infection status. Among Tc+ individuals, those with cardiac insufficiency had higher levels of BNP, NTproBNP, troponin I, MMP-2, TIMP-1, and TIMP-2 than those with normal ejection fraction and left ventricular diameter. No individual marker distinguished between the two earliest Tc+ stages, but in ROC-based analyses, MMP-2/MMP-9 ratio was significantly higher in those with than those without ECG abnormalities. Conclusions: BNP, NTproBNP, troponin I, MMP-2, TIMP-1, and TIMP-2 levels rose with increasing severity stage but did not distinguish between Chagas cardiomyopathy and other cardiomyopathies. Among Tc+ individuals without cardiac insufficiency, only the MMP-2/MMP-9 ratio differed between those with and without ECG changes.
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    Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia
    (Oxford University Press on behalf of the Infectious Diseases Society of America, 2015-06-02) Kaplinski, Michelle; Jois, Malasa; Galdos-Cardenas, Gerson; Rendell, Victoria R.; Shah, Vishal; Do, Rose Q.
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    Hyperendemic Chagas Disease and the Unmet Need for Pacemakers in the Bolivian Chaco
    (Alain Debrabant, US Food and Drug Administration, United States of America, 2014-06-05) Clark, Eva H.; Sherbuk, Jackie; Okamoto, Emi; Jois, Malasa; Galdos-Cardenas, Gerson; Vela-Guerra, Julio; Menacho-Mendez, Gilberto Silvio
    Morbidity and mortality from Chagas cardiomyopathy have declined over the last three decades because of disruption of domestic vector-borne transmission, improved Trypanosoma cruzi infection treatment programs, and increasing availability of advanced cardiac care. However, the Gran Chaco, an ecological zone that includes parts of Argentina, Bolivia, and Paraguay, continues to struggle with extremely high rates of vector infestation and T. cruzi infection. In addition, this region is one of the poorest in the world, with most individuals living on less than US$2 per day. We estimate that thousands of patients are in need of pacemakers secondary to advanced Chagas cardiomyopathy. However, the vast majority of these individuals lack the resources to obtain these life-saving devices. A collaborative effort must be made by pacemaker donation programs, local implantation hospitals, and the governments of countries affected by Chagas disease to address this unmet need. With the necessary cooperation and infrastructure, pacemaker reuse programs have the potential to offer thousands of low-cost devices to impoverished patients with advancing Chagas cardiomyopathy.
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    Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia
    (Oxford University Press on behalf of the Infectious Diseases Society of America, 2015-06-02) Kaplinski, Michelle; Jois, Malasa; Galdos-Cardenas, Gerson; Rendell, Victoria R.; Shah, Vishal; Do, Rose Q.; Marcus, Rachel; Burroughs Pena, Melissa S.; Abastoflor, Maria del Carmen; LaFuente, Carlos; Bozo, Ricardo; Valencia, Edward; Verastegui, Manuela; Colanzi, Rony; Gilman, Robert H.; Bern, Caryn