Área Salud

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La Unidad Académica Santa Cruz comprometida con el desarrollo científico al servicio de la sociedad boliviana cuenta con dos unidades de investigación en el área de salud: Instituto de investigación en Medicina conformado el año 2012, con más de 6 años de experiencia en proyectos de investigación en el área de enfermedades infecciosas y otros, y la carrea de Odontología, que cuanta con una gran cantidad de producción científica en torno a rehabilitación oral y otras temáticas abordadas desde la clínica odontológica. La participación en investigación de estudiantes de pre grado es fundamental, la misma se ve reflejada y conglomerada en dos sociedades científicas: Sociedad Científica de Estudiantes de Medicina y la Sociedad Científica de estudiantes de Odontología.

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A Systematic Review of the Efficacy of Glabellar Botulinum Toxin Injections Compared to Acupuncture in the Treatment of Borderline Personality Disorder
(2024) Portillo Saavedra, Natalia; Vargas Sandoval, Ericka; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Borderline personality disorder (BPD) is a complex psychiatric condition characterized by pervasive emotional dysregulation, impulsivity, and difficulties in cognitive control. Patients often exhibit heightened reactivity to negative emotional stimuli, which is associated with increased activity in the amygdala and decreased functionality in the prefrontal cortex during tasks that require inhibition. Given these neurobiological underpinnings, glabellar botulinum toxin (BTX) injections have emerged as a potential treatment option due to their ability to disrupt facial feedback mechanisms that may exacerbate emotional responses.
Abordagem interdisciplinar do tratamento em paciente adulto com múltiplas perdas dentárias
(2019) Antelo, Oscar Mario; Cuellar Caballero, Gabriela; Amadi, Ana Karolliny; Schneider, Neblyssa Agatha; Motohiro Tanaka, Orlando
Este relato de caso ilustra o tratamento interdisciplinar realizado em uma paciente adulta de 43 anos de idade, Classe II esquelética, perfil convexo, maloclusão Classe I de Angle com múltiplas perdas dentárias e extrusão dos molares superiores do lado direito com redução do espaço protético para reabilitação. O tratamento ortodôntico foi realizado para preparar os espaços desdentados para reabilitação com implantes dentários e próteses. Durante o nive- lamento dos arcos dentários, mini-implantes foram posicionados entre o primeiro e o segun-do molar superior, no lado direito, nas corticais vestibular e palatina, respectivamente, para auxiliar na intrusão desses dentes, aumentando o espaço protético mandibular. Na fase de finalização, implantes osseointegrados foram colocados para a reabilitação dos dentes ausen- tes. Após três anos e quatro meses de tratamento, os objetivos foram atingidos e o aparelho ortodôntico foi removido. A mecânica com mini-implantes ortodônticos favoreceu a intrusão dos molares superiores e a reabilitação bem-sucedida do caso, devolvendo a estética, a função dentária e mantendo os resultados estáveis após um ano e cinco meses de acompanhamento.
Advancing Surgical Approaches for Trigeminal Neuralgia A Meta-Analysis of Endoscopic and Microscopic Microvascular Decompression
(2024) Hjeala Varas, Amir; Castillo Sulca, Gabriel; Manrique, Miguel; Carrara Sodre, Katerine; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Biomarkers in Trypanosomacruzi -Infected and Uninfected Individuals with Varying Severity of Cardiomyopathy in Santa Cruz, Bolivia
(PLOS Neglected Tropical Diseases, 2014) Okamoto, Emi E.; Sherbuk, Jacqueline E.; Clark, Eva H.; Marks, Morgan A.; Gandarilla, Omar; Galdos-Cardenas, Gerson; Vasquez-Villar, Angel; Choi, Jeong
Background: Twenty to thirty percent of persons with Trypanosoma cruzi infection eventually develop cardiomyopathy. If an early indicator were to be identified and validated in longitudinal studies, this could enable treatment to be prioritized for those at highest risk. We evaluated cardiac and extracellular matrix remodeling markers across cardiac stages in T. cruzi infected (Tc+) and uninfected (Tc2) individuals. Methods: Participants were recruited in a public hospital in Santa Cruz, Bolivia and assigned cardiac severity stages by electrocardiogram and echocardiogram. BNP, NTproBNP, CKMB, troponin I, MMP-2, MMP-9, TIMP-1, TIMP-2, TGFb1, and TGFb2 were measured in specimens from 265 individuals using multiplex bead systems. Biomarker levels were compared between Tc+ and Tc2 groups, and across cardiac stages. Receivers operating characteristic (ROC) curves were created; for markers with area under curve.0.60, logistic regression was performed. Results: Analyses stratified by cardiac stage showed no significant differences in biomarker levels by Tc infection status. Among Tc+ individuals, those with cardiac insufficiency had higher levels of BNP, NTproBNP, troponin I, MMP-2, TIMP-1, and TIMP-2 than those with normal ejection fraction and left ventricular diameter. No individual marker distinguished between the two earliest Tc+ stages, but in ROC-based analyses, MMP-2/MMP-9 ratio was significantly higher in those with than those without ECG abnormalities. Conclusions: BNP, NTproBNP, troponin I, MMP-2, TIMP-1, and TIMP-2 levels rose with increasing severity stage but did not distinguish between Chagas cardiomyopathy and other cardiomyopathies. Among Tc+ individuals without cardiac insufficiency, only the MMP-2/MMP-9 ratio differed between those with and without ECG changes.
Botulinum Toxin as an Adjunct Treatment for Borderline Personality Disorder: A systematic Review of 144 Patients
(2024) Cespedes Canavire, Sedrich; Osorio Ortega, Valentina; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Caracterización Gingival en Prótesis Total Removible
(2018) Herrera, Fabricio Alejandro; Viveros Vargas, Daniela; Castedo Soria, Ly Massiel; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia) Odontología
Consequences of inadequate exclusive breastfeeding in Children from latin america: a systematic review
(2024) Franco, Sergio; Salazar, Mateo; Vilca, Najhavy; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Introduction: Exclusive breastfeeding is essential for the healthy growth and physical and mental development of your baby. Not breastfeeding or breastfeeding for less than six months increases the risk of the child developing various diseases. Objective: To gather and explain the consequences of not providing exclusive breastfeeding to children in Latin America. Methodology: Scientific articles were searched on the PubMed and Scielo platforms, following the PRISMA method. Specific criteria were used to decide which articles to include or exclude in this study. In total, 13 selected articles were analyzed. Results: The reviewed research shows that insufficient breastfeeding or breastfeeding for less than six months can lead to issues such as developmental and growth delays, overweight and obesity during adolescence, and underweight in childhood. It also indicates a high risk of respiratory diseases such as pneumonia and bronchiolitis, skin problems like allergic dermatitis and atopic dermatitis, iron deficiency anemia, vitamin A deficiency, and severe dehydration. Conclusion: It is important to have new information about the risks of breastfeeding in our society. This helps people understand its significance in preventing diseases and ensuring proper growth for babies.
Correction of severe anterior open bite using tongue spurs and temporary anchorage devices
(2023) Antelo, Oscar Mario; Antelo Justiniano, Jorge; Adriano Reyes, Ariel; Luiz Mota-J unior, Sergio; Motohiro Tanaka, Orlando
Depression, anxiety and stress in medical students during COVID-19 pandemic: A systematic review
(2024) Cornejo Mollo, Shaaron Withney; Cruz Zambrana, Alejandra Janice; Encinas-Saucedo, Alejandra
Determinación de la Dimensión Vertical de Oclusión a través de un Instrumento Craneométrico
(S/f) Murialdo, María Inés; Pacheco Chavez, Hugo Eduardo; Castedo Soria, Ly Massiel; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia) Odontología
DETERMINACIÓN DE LOS FACTORES DE RIESGO DE DIABETES EN PERSONAL ADMINISTRATIVO DE UNIVERSIDADES DE LATINOAMÉRICA, ESTUDIO MULTICÉNTRICO
(2021) Padilla, Mauricio Jensen; Bellatin-Luque, Nadine Sofía; Mercado Roca, Luis Adolfo; Universidad Católica Boliviana “San Pablo”. Santa Cruz de la Sierra, Bolivia.; Universidad Católica de Santa María. Arequipa, Perú
La Diabetes Mellitus se ha convertido en uno de los problemas de salud pública más importantes globalmente, con un crecimiento acelerado en el número de personas afectadas. En las diversas universidades, el personal administrativo experimenta arduas horas de trabajo, generalmente labores de oficina que implican estar sentado durante horas, con desequilibrios en la alimentación y las jornadas sin descanso en un clima de permanente tensión y estrés, lo que produce efectos negativos en la salud de los trabajadores. El objetivo fue determinar estos factores de riesgo para enfermedades crónicas no transmisibles como la diabetes mellitus.
Determinantes sociales asociados al autoinforme de síntomas, acceso al testeo y diagnóstico de COVID-19 en el Estado Plurinacional de Bolivia
(2022) Arias-Uriona, Ana M.; Pérez, Esdenka; Llanos, Javier; Cuellar, Rafael; Galarza, Pamela Y.
Objetivo. Identificar la prevalencia del autoinforme de síntomas, del acceso al testeo y del diagnóstico de la enfermedad por el coronavirus del 2019 (COVID-19, por su sigla en inglés), así como su asociación con determinantes sociales de la salud (DSS). Métodos. Estudio transversal con una muestra de 11 728 hombres y 12 612 mujeres mayores de 17 años, con base en la Encuesta Nacional de Hogares 2020. Las variables dependientes fueron el autoinforme de síntomas, de acceso al testeo y de una prueba positiva para COVID-19. Las variables independientes fueron la edad, el nivel de educación, la zona de residencia y geográfica, la etnia, el tipo de hogar, el ingreso per cápita, la actividad y el seguro de salud. Se calcularon prevalencias, asociaciones bivariadas y modelos de regresión logística binomial (razón de momios [OR] e intervalo de confianza del 95% [IC95%]). Resultados. Del total de personas incluidas, 16% notificó síntomas, 10% un testeo y 4,2% una prueba posi- tiva para COVID-19. Existieron desigualdades en la notificación de síntomas de COVID-19, con una mayor probabilidad en las mujeres cuyos ingresos habían disminuido (OR: 1,7; IC95%: 1,2-2,4) y las personas des- empleadas (OR: 1,2; IC95%: 1,1-1,4 para los hombres y OR:1,3; IC: 1,5-1,5 para las mujeres). En cambio, con respecto al acceso a las pruebas diagnósticas, la mayor probabilidad se observó en personas con educación superior (OR: 2.4; IC95%: 1,9-2,9 para los hombres y OR: 2,7; IC95%: 2,2-3,4 para las mujeres), cuyos ingre- sos se mantuvieron (OR: 1,5; IC95%: 1,3-1,9 para los hombres y OR: 1,7; IC95%: 1,4-2,0 para las mujeres) y del cuartil de ingreso per cápita en el hogar más alto (OR: 2,0; IC95%:1,6-2,5 para los hombres y OR: 1,6; IC95%: 1,3-2,0 para las mujeres). La probabilidad de notificar síntomas, realizarse una prueba y el diagnós- tico para COVID-19 aumentó con la edad, para las personas que contaban con seguro de salud y residentes en los llanos; por otra parte, disminuyó para residentes de zonas rurales. Conclusiones. Existen desigualdades en el acceso al testeo y en la notificación de síntomas de la COVID-19.
Effectiveness and Safety of Probiotics Versus Conventional Antifungal Treatments for Vulvovaginal Candidiasis in Non-Pregnant Women: A Systematic Review
(2024) Garcia Agreda, Nicole Quiroga; Moreno Almanza, Mónica C.; Ribera Camacho, Fabio E.; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Background: Vulvovaginal candidiasis (VVC) is a common gynecological condition that can significantly affect the quality of life. Conventional antifungal treatments, while effective, are associated with potential side effects and resistance issues. Probiotics have emerged as a potential alternative or complementary treatment by targeting the vaginal microbiota. This review aims to evaluate whether probiotics, antifungal treatments, or a combination of both are more effective in managing VVC.
Effectiveness of psychological therapies versus antidepressants in adults with major depression: a systematic review
(2024) Antelo Candia, Nohelia; Coronado Camacho, Génesis Jassid; Oshiro Nakagawa, Mie
Effects of chamomile on individuals with sleep disorders: A systematic review
(2024) Pereira de Sousa Ramirez, Mariana; Zaghini Santos, Maria Eduarda; Gonzales Soria, Natalia
Sleep is essential for maintaining both physical and mental well-being, yet many people struggle with sleep disorders like insomnia or sleep apnea. Traditional remedies, such as chamomile, have become popular as natural alternatives for improving sleep. This systematic review examines the effectiveness of chamomile, focusing on how it impacts sleep quality, duration, and the ability to fall asleep.The review includes four studies that explored different forms of chamomile, such as teas, extracts, and essential oils. Results showed promising effects, especially in reducing stress and anxiety, which are major factors affecting sleep. Some participants experienced better sleep quality and shorter times to fall asleep, but the overall results were inconsistent, particularly when looking at objective measures like total sleep time. Importantly, chamomile was found to be safe, with no serious side effects reported. While chamomile shows potential, this review highlights several limitations, including small sample sizes and differences in how the studies were conducted. To truly understand chamomile’s benefits, larger studies with standardized methods and more robust testing are needed. Despite these gaps, chamomile remains a hopeful option for those seeking natural ways to improve their sleep.
Efficacy and safety of trofinetide in patients with Rett syndrome: a systematic literature review
(2024) Menacho Meroly, Saucedo Camila
Introduction Rett syndrome (RTT) is a rare neurodevelopmental disorder with limited treatment options. Trofinetide has emerged as a potential therapeutic agent due to its neuroprotective and anti-inflammatory properties. This systematic review evaluates the efficacy and safety of trofinetide in patients with Rett syndrome. Methods We identified 44 articles from two databases (PubMed and Scopus). After removing duplicates, we applied the inclusion criteria, which were restricted to systematic reviews and meta-analyses of randomized controlled trials (RCTs) published within the last 5 years, available in English, and reporting efficacy outcomes measured with validated tools such as the Rett Syndrome Behavior Questionnaire (RSBQ) and the Clinical Global Impression-Improvement (CGI-I). Non-randomized trials and studies with insufficient data were excluded. Results This review included three studies with 916 patients on trofinetide for Rett syndrome. Trofinetide showed significant improvements in RSBQ (MD: -3.40 to -3.53) and CGI-I scores (MD: -0.34 to -0.35). Common side effects were diarrhea and vomiting, but no severe adverse events were reported. Conclusions This systematic review supports the efficacy of trofinetide in improving behavioral and functional outcomes in Rett syndrome. The treatment demonstrated significant reductions in symptom severity, particularly in communication and motor skills, as measured by the Rett Syndrome Behavior Questionnaire (RSBQ) and Clinical Global Impression-Improvement (CGI-I). While trofinetide was generally well-tolerated, common side effects like diarrhea and vomiting were reported. Further research with longer follow-up periods is needed to confirm the long-term efficacy and safety of trofinetide in RTT patients.
Efficacy of Protein-Based Therapies in Modulating Pathology and Symptoms of Alzheimer’s Disease: A Systematic Review
(2024) Rivero Paniagua, Yhazmin; Feeney Camacho, Nicole; Urioste Daza, Jhuliana; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia)
Introduction: Beta-amyloid plaques and tau neurofibrillary tangles disrupt brain function, leading to the progressive cognitive and functional decline characteristic of Alzheimer’s Disease (AD). Current treatments provide only symptomatic relief, failing to address the underlying pathology. Protein-based therapies, including monoclonal antibodies and recombinant protein vaccines, aim to target these pathological mechanisms by clearing beta-amyloid deposits and modulating tau activity. This review evaluates the efficacy of these therapies in improving cognitive and functional outcomes while exploring their limitations and potential. Methods: This systematic review was conducted following PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions (version 6.3). A comprehensive search of PubMed, Scopus, and Web of Science was performed. Inclusion criteria focused on studies evaluating protein-based therapies targeting amyloid-beta or tau in Alzheimer’s Disease. Data on cognitive and functional outcomes, safety, and biomarkers were extracted and synthesized to identify trends and gaps in the evidence. Results: Eight studies involving 724 participants met the inclusion criteria. Monoclonal antibodies, such as aducanumab, reduced amyloid-beta plaques within 24–48 weeks, but cognitive improvements were inconsistent. Recombinant vaccines, like Lu AF20513, induced strong immune responses in 65–80% of patients, especially with immunostimulant patches. Biomarkers such as alpha-2-macroglobulin showed promise in monitoring treatment efficacy. Adverse events, including mild infusion reactions, were more frequent with antibody therapies, highlighting the need for further optimization. Conclusion: Protein-based therapies show potential in Alzheimer’s Disease treatment by targeting amyloid-beta plaques and tau pathology. Monoclonal antibodies and recombinant vaccines offer promising results in reducing pathological hallmarks and improving immune responses. However, cognitive and functional benefits remain inconsistent, and adverse events are common. Further research is necessary to optimize these therapies, validate biomarkers, and ensure broader clinical applicability.
Esporões linguais para a interceptação da mordida aberta anterior dentária. Em uma consulta?
(2020) Antelo, Oscar Mario; Meira, Thiago Martins; Castilhos, Jussimar Scheffer; Barboza Bueno, Nathan; Tanaka, Orlando
Estandarización del Jig de Lucia
(2016) Flores Galetovic, Bruno Marcelo; Pacheco Chavez, Hugo Eduardo; Universidad Católica Boliviana “San Pablo” (Santa Cruz, Bolivia) Odontología
EXPANSIÓN DENTOALVEOLAR CON ALINEADORES INVISALIGN PARA REDUCIR LOS CORREDORES BUCALES, ALIVIAR EL APIÑAMIENTO Y MEJORAR LA ESTÉTICA DE LA SONRISA
(2022) García Alatorre, Hector; Antelo, Oscar Mario; Meira, Thiago Martins; Tanaka, Orlando
RESUMEN El sistema Invisalign es una modalidad de tratamiento efectivo para tratar arcos dentarios contraídos y apiñamiento mandibular severo. El objetivo de este artículo es presentar un caso clínico de un paciente adulto con maloclusión Clase I, arcos dentarios contraídos, corredores bucales grandes y apiñamiento mandibular severo con torus mandibular. La biomecánica empleada se enfocó en expansión dentoalveolar de ambos arcos, asociada con desgaste interproximal, lo que resultó en una reducción de los corredores bucales, así como arcos dentarios alineados y nivelados con adecuada intercuspidación. Los resultados se mantuvieron estables después de 1 año de seguimiento. ABSTRACT The Invisalign system is an effective treatment modality for contracted dental arches and severe mandibular crowding. The objective of this article is to present a clinical case of an adult patient with Class I malocclusion, contracted dental arches, large buccal corridors, and severe mandibular crowding with torus mandibularis. The biomechanics employed focused on the expansion of maxillary and mandibular dental arches associated with interproximal stripping, resulting in a reduction of the buccal corridors as well as well aligned and leveled teeth with proper intercuspation. Results were stable after 1 year of follow-up.